The human lymphatic system consists of a vast network of vessels that drain protein-rich fluid in tissues and transport it to lymph nodes. When the machinery goes awry and the lymphatic vessels don't drain properly, the fluid accumulates in the tissues, leading to painful swelling known as lymphedema. A Cornell-led collaboration built a 3D in-vitro model of a functional human lymphatic vessel that revealed a surprising mechanism that can jam up the necessary drainage: a protein expressed in lymphatic endothelial cells called rho-associated protein kinase 2 (ROCK2).

https://www.miragenews.com/targeting-unsuspected-protein-reverses-1096389/

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