In their comprehensive meta-analysis (comprising 221 randomized controlled trials involving 65,601 patients), researchers investigated the effectiveness of various pharmacological therapies for acne vulgaris across diverse age groups and genders. The articles described 37 interventions, with a median patient age of 20 years old and median duration of treatment of 12 weeks. The median total, inflammatory and non-inflammatory lesion counts were 71.5, 27 and 44, respectively. The study revealed that oral isotretinoin was the most effective treatment (mean difference 48.

https://www.miragenews.com/oral-isotretinoin-tops-most-effective-acne-1053481/

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