Esophageal adenocarcinoma (EAC) is a highly lethal cancer, with a five-year survival rate of less than 20 percent. Although a precursor lesion to EAC, called Barrett's esophagus (BE), is present in roughly seven percent of middle-aged adults, less than one percent of BE patients will progress to EAC, making it difficult to determine which individuals are at risk of developing this deadly cancer. To better understand why only a small fraction of individuals with BE develop EAC, investigators from the Mass General Cancer Center , a member of the Mass General Brigham healthcare system, used genomic databases to identify genetic drivers associated with EAC.

https://www.miragenews.com/new-genetic-drivers-for-esophageal-cancer-1054622/

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