LONDON—Johnny Depp became a global megastar playing off-beat characters from Willy Wonka to Captain Jack Sparrow, until his destructive off-screen lifestyle threatened to permanently derail his career. Pouring his own eccentricities into his roles, Depp earned a reputation as both heartthrob and indie darling through sensitive performances in films such as 'Edward Scissorhands' and 'What's Eating Gilbert Grape.' He stepped into another level of fame fronting Disney's billion-dollar 'Pirates of the Caribbean' franchise as the rum-swilling sea dog Captain Jack Sparrow—partly inspired by one of his many heroes, Rolling Stones guitarist Keith Richards.

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