Bioengineers can tailor the genomes of cells to create "cellular therapies" that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch on bioengineered genes without occasionally turning on some of the cell's naturally occurring genes. Caleb Bashor (Photo by Jeff Fitlow/Rice University) In a study published online in Cell , bioengineers from Rice University, Boston University, Harvard Medical School, Dartmouth College and Harvard University's Wyss Institute showed they could all but eliminate such "off-target" gene activations using a method that takes its cue from nature.

https://www.miragenews.com/weaker-transcription-factors-excel-in-1065128/

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