Researchers have used CRISPR gene editing, stem cells and human neurons to understand the role of a gene that is commonly mutated in autism. This new study, published today in The American Journal of Human Genetics , ties mutations in the gene CHD8 with a broad spectrum of molecular and cellular defects in human neurons. Autism is a highly heritable disorder that is on the rise with approximately 1 in 40 children in the U.S. receiving an autism diagnosis. Over the past decade, sequencing studies have found many genes associated with autism, but it has been challenging to understand how mutations in certain genes drive complex changes in brain activity and function.

https://www.miragenews.com/gene-editing-uncovers-genome-autism-link-in-1098325/

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