Organosulfur(VI) fluoride compounds display excellent chemical stability, and yet can efficiently realize diverse linkages via the activation of specific conditions. Based on its unique nature, Sharpless, Dong and coworkers introduced SuFEx as a new generation of click reaction in 2014 (Figure 1a). Since then, SuFEx has become an active research area, frequently occuring in chemical biology, drug discovery, and material chemistry. Importantly, a selection of SuFEx linkers has been developed (Figure 1b), among which FSO 2 -containing molecules (I-IV) occupy a predominant position.

https://www.miragenews.com/scientists-develop-sufex-as-next-gen-click-1043879/

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