Probal Rashid/LightRocket via Getty Images (NEW ORLEANS) -- A federal appeals court in New Orleans on Wednesday heard arguments in a high-stakes bid to invalidate FDA approval of the most widely used abortion medication in the country more than two decades after it hit the market and despite its safe use by millions of women. Three judges on the Fifth Circuit Court of Appeals -- one of the most conservative courts in the country -- appeared open to limiting access to the medication as they questioned a Biden administration attorney about FDA's assessment of the drug mifepristone's safety and effectiveness.

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