An anti-obesity drug can be delivered selectively to the liver using a nanogel-based carrier, according to a study. Synthetic thyroid hormone mimics are promising treatments for metabolic diseases including metabolic dysfunction-associated steatohepatitis (MASH), high cholesterol, type 2 diabetes, and inflammatory liver disease; however, the molecules are not highly bioavailable or potent, which are necessary to see significant weight loss. S. Thayumanavan and colleagues designed a nanogel-based carrier with anionic moieties on the surface that directs a thyromimetic exclusively to liver cells in mice.

https://www.miragenews.com/anti-obesity-drug-successfully-delivered-to-1073953/

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