According to textbooks, proteins work by folding into stable 3D shapes that, like Lego blocks, precisely fit with other biomolecules. Yet this picture of proteins, the "workhorses of biology," is incomplete. Around half of all proteins have stringy, unstructured bits hanging off them, dubbed intrinsically disordered regions, or IDRs. Because IDRs have more dynamic, "shape-shifting" geometries, biologists have generally thought that they cannot have as precise of a fit with other biomolecules as their folded counterparts, and as such, assumed these thread-like entities may contribute less significantly to overall protein function.

https://www.miragenews.com/underrated-protein-parts-key-to-essential-life-1095698/

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