When King Henry VIII took the crown in 1509 at the age of 17, members of his court noted he was a scholar and an athlete. He was thoughtful, wise and considerate. But when he died in 1547, many feared him as a petty tyrant who hysterically executed his enemies, including two of his six wives. His change in personality has long left scholars wondering — what was that guy's deal? Medical historians have considered whether the king had diabetes, hypothyroidism or McLeod syndrome, a rare genetic disorder that can affect the brain.

https://www.discovermagazine.com/mind/could-brain-injuries-explain-king-henry-viiis-tyrant-behavior

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